The Evolutionary, Developmental, and Therapeutic Effects of MDMA in Animals
One Health Discovery Series | June 2021
Care for the Healer (CFTH) is thrilled to host Dr. Gül Dölen, M.D., Ph.D., and associate professor at the Johns Hopkins Department of Neuroscience for our June One Health Discovery Series episode.
Dr. Gül is an extremely accomplished scientist whose research has been making waves within the Neuroscience and Psychedelic Medicine communities. While her research interests are vast; we plan to discuss her research related to the use of 3-4-methylenedioxymethamphetamine (MDMA) in rodents and octopuses.
She has found consistent pro-social effects of MDMA across species with vastly different neurological systems.
Dr. Gül is an extremely accomplished scientist whose research has been making waves within the Neuroscience and Psychedelic Medicine communities. While her research interests are vast; we plan to discuss her research related to the use of 3-4-methylenedioxymethamphetamine (MDMA) in rodents and octopuses.
She has found consistent pro-social effects of MDMA across species with vastly different neurological systems.
MDMA (3-4-methylenedioxymethamphetamine) is a phenethylamine that produces euphoria in most individuals, and is an active ingredient in the street drug ‘ecstasy’ or ‘molly. The MDMA molecule has been getting a lot of press recently for its breakthrough potential as a treatment for anxiety and PTSD. Recent successful Phase 3 FDA clinical trials demonstrate the molecule’s real potential to become a part of a new paradigm of mental health treatment.
While research is still growing, the function of MDMA in humans is theorized to occur via a few different mechanisms based on fMRI studies. For people with anxiety, it appears to function by decreasing the communication between the medial temporal lobe and medial prefrontal cortex; a part of our brain that is responsible for emotional control. In anxious people, this region of the brain is firing at a higher rate. For PTSD patients, MDMA appears to function by increasing communication between the amygdala and hippocampus.
While research is still growing, the function of MDMA in humans is theorized to occur via a few different mechanisms based on fMRI studies. For people with anxiety, it appears to function by decreasing the communication between the medial temporal lobe and medial prefrontal cortex; a part of our brain that is responsible for emotional control. In anxious people, this region of the brain is firing at a higher rate. For PTSD patients, MDMA appears to function by increasing communication between the amygdala and hippocampus.
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While researchers are striving to find out more about how MDMA affects brain function, Dr. Dölen’s research on octopuses with MDMA challenges what we currently know in multiple areas of medicine. For one – octopuses do not have amygdalas!....so, there must be more to the picture of this molecule’s mechanism of action.
Dr. Dölen is also thinking about psychedelics beyond their immediate euphoric effects. While a lot of the focus within the psychedelic medicine community is focused on neuroplasticity, she and her lab bring another perspective - ‘critical periods’ of brain development and function. When we are young, our brain is a sponge and creates new neural pathways to absorb all our new experiences. As we grow, these pathways harden and close. She suspects that psychedelics such as MDMA allow the brain to re-enter this child-like state. If true, this opens up a world of potential for mental health and physical injuries or disease. |
Of course, we at CFTH are always interested in species beyond humans too!
Which of our veterinary species patients could benefit from an opening of the ‘critical period’ combined with pro-social behaviours? Dr. Casara Andre will be bringing this veterinary perspective to the conversation as we continue to explore these uncharted waters.
We hope to have you attend and be a part of the conversation!
Which of our veterinary species patients could benefit from an opening of the ‘critical period’ combined with pro-social behaviours? Dr. Casara Andre will be bringing this veterinary perspective to the conversation as we continue to explore these uncharted waters.
We hope to have you attend and be a part of the conversation!
Before-the-Conversation References
- How MDMA, octopuses, and Gül Dölen reopen minds
- Study reveals how ecstasy acts on the brain and hints at therapeutic uses
- Effects of acutely administered MDMA on spontaneous brain function
- Oxytocin-dependent reopening of a social reward learning critical period with MDMA
- A conserved role for serotonergic neurotransmission in mediating social behavior in octopus
Guests:
During this discussion, we welcome guests Dr. Gül Dölen and Dr. Casara Andre as we explore the One Health potential of MDMA in animals.
During this discussion, we welcome guests Dr. Gül Dölen and Dr. Casara Andre as we explore the One Health potential of MDMA in animals.
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Dr. Gül Dölen | Neuroscientist
Dr. Gül is an Associate Professor in the Department of Neuroscience, Brain Science Institute, Wendy Klag Center for Autism & Developmental Disabilities, Kavli Neuroscience Discovery Institute. Dr. Dölen is the recipient of several prestigious awards including: the Joukowsky Family Foundation Outstanding Dissertation Award, the Conquer Fragile X Rising Star Award, the Angus MacDonald Award for Excellence in Undergraduate Teaching, theSociety for Social Neuroscience Early Career Award, the Searle Scholars Award, and the Johns Hopkins University President’s Frontier Award. She joined the faculty at Johns Hopkins in 2014.
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Dr. Casara Andre | Veterinarian
Veterinarian and Founding President of Care for the Healer, Dr. Casara Andre contributes her experience working with non-verbal, non-human mammals with behavioral conditions and thoughts on if and how psychedelic assisted therapy might be safely approached when working with veterinary species.
Dr. Andre is dedicated to providing practical education and harm reduction training to the emerging veterinary cannabis and psychedelic fields. She firmly believes that scientific curiosity can and will open unexpected, exciting, and hugely beneficial opportunities within this field but also that scientific rigor and scrutiny must never be neglected. She is dedicated propagating sustainable, community-minded paradigms that ensure the well-being of both pets and the veterinary practitioners that care for them. |
Facilitated by:
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Clint Latham | Cyber Security
Clint Latham is the owner of Lucca Data Security and the host of The People of Veterinary Medicine Podcast. With two senior yorkies, Clint understands the need to have a trusted veterinarian to care for his family members.
Clint’s goal is to help uncover the mystery of IT & data security for veterinarians across the country so that they can focus on what is most important: quality care for our four-legged family members. While working and speaking with veterinary hospitals all across the country, Clint saw a drastic increase in the number of cyber attacks to private practice. Clint decided to build a solution to keep hospitals protected while simultaneously keeping IT costs under control and providing veterinary hospitals the services they need and nothing they don't. |
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